16 July, 2012

SEXUAL DYSFUNCTION - NEW DRUG IN INDIA - UDENAFIL

TRADE NAME - ZYDENA
TRADE NAME IN INDIA - UDEZIRE
Erectile dysfunction (ED) is an inability to achieve or sustain an erection suitablefor sexual intercourse. Sexologists say at least 10% men in India may have to use these drugs at some point. Studies have shown that 40% of men up to the age of 40 years have ED andit goesup 70% by 60 years.
The commonly prescribed drugs for the disorder in India are sildenafil(Viagra) and tadalafil,which belong to a category called phosphodiesterasetype5 drugs. Now, Zydus, a pharmaceutical company, has got exclusive permission to sell udenafil.



Mechanism Of Action

Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degeneration of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is produced by increased penile blood flow caused by the relaxation of penile arteries and corpus cavernosal smooth muscle. This reaction is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by udenafil reinforces erection by increasing the amount of cGMP.

Udenafil Dosing and Administration

Pills taken by mouth, with or without food, for 30 minutes before the alleged sexual activity.
Recommended dose – 100 mg. If necessary, taking into account individual performance and portability, the dose may be increased to 200 mg. The maximum recommended frequency of application – 1 times / day.

Side effects of Udenafil

Palpitations, prolonged erections, flushing, dizziness eye pain, increased lacrimation, nasal congestion, headache.

Cautions

Sexual activity is a potential risk for patients with cardiovascular disease, hypertension, so treatment of sexual dysfunctions, should not hold for men with diseases, when sexual activity is not recommended.
Also, there is no clinical data on the use of Udenafil for patients older than 71 y.o.

Advantages

  • rapid and predictable onset of action
  • provides necessary to erection hardness
  • increases the axial load on the penis
  • reduces the time of the refractory period (time after ejaculation until the next erection)
  • optimal duration of up to 24 hours
  • high safety profile in the class of PDE-5 inhibitors
  • Drinking alcohol and fatty food does not affect the action of Udenafil

The new drug will be priced at 575 per tablet, a little lesser than Viagra.

84 comments :

  1. Nice Article! Thanks for sharing with us.

    Penetrex South Africa

    ReplyDelete
    Replies
    1. Hi Doctor ,

      Am not diabetic shall i use it(Udzire ) for longer sex & longer erection

      Delete
    2. hi,

      Udzire is for people who are not able to attain or sustain erection... these kind of tabs have their own effects on the cardiovascular system so my answer is NO!

      Delete
  2. Thanks for such a valuable post.just a moment back I was searching for the information on the erectile dysfunction and now I am here. such a very impressive post. thanks a lot.

    ReplyDelete
  3. Does it harm me if I use it when its required before sexual activity as a habit

    ReplyDelete
    Replies
    1. no these type of drugs are usually safe in recommended dosages.. overdose of any drug is harmful for sure

      Delete
  4. Very nice. 1 tablet costing 575 for one day consumption is too high to use by the people in middle class. Is there any possibility to get it at less.

    How to get it? is it available in the Medical shops?

    ReplyDelete
  5. Pl mention the brand name at leading pharmacy, I think it will not be difficult for then, if possible pl mention the company name also......

    ReplyDelete
  6. Excellent blog very nice and unique information related to SEXUAL DYSFUNCTION. Thanks for sharing this information.
    Sildenafil Citrate

    ReplyDelete
  7. Please name a pharmacy in royapettah where we can get this.

    ReplyDelete
  8. I do thank you for your supreme dedication in wanting to help people with this problem, and appreciate your efforts in giving information on this illness.

    ReplyDelete
  9. ANY GENERIC BRAND AVAILABLE IN CHEMISTS SHOP IN DELHI OD UDENAFIL

    ReplyDelete
    Replies
    1. hi,
      since this is a patented drug you wont find any generic brands.. right now only one company is selling this drug

      Delete
  10. Does use of this drug cause rise in blood pressure ??

    ReplyDelete
  11. hi,
    this drug is pretty new in the market and long term safety studies are not available. as far as I know these group of drugs do not increase b.p. as we don't have long time studies its better to advise caution...

    ReplyDelete
  12. Thanks for the Information. My urologist Dr. B. Kundu of CMRI, Kolkata pescribed me this drug. But this in not available in drug stores. I need to call the MR of Zydus at Rs.1000/- for 2tabs. Home supply

    ReplyDelete
    Replies
    1. Finally I have tried the drug for the first time. I am suffering from Type 2 diabetes for the last 12 years and having ED problem for the past 2 years. Yes the drug, as it claims, is wonderful. It gave prolonged erection and my wife did enjoy a lot. But ……. Yes, there is a BUT. During the erection there was very little or almost no sensation. As if the penis is not a part of my body. Although it’s a very good experience for my wife and she thinks that old days are back but I missed the pleasure of the final moment as there was no sensation. And yes the next day I had headache throughout the day but that may be due to the sleepless night.

      Delete
    2. Ok!!!! After trying the second pill I found that the initial problems I faced during the first trial gone. This drug is something that causes wonder!!!!!!!!!!!!(Please consult a urologist/diabetologist before using any drug.)

      Delete
    3. thats a very good point you made... any of these drugs should be taken after discussing with urologist & diabetologist. i am happy the drug worked for you..

      Delete
  13. thanks a lot for this valuable information. iam also sufffring from Type 2 diabites from last 2 years, i am taking Galver 50/500 tablet + Vitamin b-12 suppliment, now my doctor has adviced me to take this tablet once in a week 30 minutes before bed.After expercing it i will share its results to all diabitc family members.

    ReplyDelete
    Replies
    1. dear keshav
      please do share the effects of this drug. i have received some good responses for this drug on my mail. although some people complain of minor and tempeory side effects the overall rating has been good. looking forward to your experience!!

      Delete
    2. dear keshav
      please do share the effects of this drug. i have received some good responses for this drug on my mail. although some people complain of minor and tempeory side effects the overall rating has been good. looking forward to your experience!!

      Delete
    3. Dear Sir,

      I used 2 tablet of 100 MG , my experience I worst with it, bad headache noisia, stress in eyes and it continued for two days continuously, for a week I suffered from headache.
      I am also not satisfied with the results, even a forzist 20 mg works good then this.

      It was not up to expectation. can you suggest some other medicine.

      regards keshav

      Delete
    4. since you are on various medications it would be wise to consult a doctor in person to decide on the treatment options. if you want to do it online you can access my website www.medicalsecondopinion.org and update your details. we will get an opinion for you from the relevant experts.

      Delete
  14. I am yet to try Udzire, however, I used Tazzle 10mg which was quite effective. However, it gave me a lot of back-ache / body ache, as it was effecting all my body muscles. Now, I will try this medicine and post my response here. NK

    ReplyDelete
  15. i had a urithra stircture after surgery, doctor told me to take udzire 100mg and duralast 60. after i took this i have sensation pbm and head ache also. doctor told me to take this for 10 days continuously since i have erection pbm and premature ejaculation. now rection is ok. is it i need to continue life long

    ReplyDelete
  16. With reference to my posts above dated March 16 & 27 and April 6 of 2013. When I used Udzire for the first time I had Headache. But the intensity of headache decreased with second and third experience. I dont care the little headache now. Now the only side effect is its price. In Kolkata market the price has raised by Rs. 25 more per tab. (with change in VAT rate as said by the supplier.he is now charging Rs.2100/- for 4 tabs.).

    ReplyDelete
    Replies
    1. hi anonymous..
      a special thanks to you for sharing info which would be quite beneficial to all. the price is high as these are patented drugs. once the patent period gets over other pharma companies can produce the same drug , so with competition rates come down...

      Delete
    2. hi,

      i am the one posted the first message, i had used 10 udzire tabs continuously with duralast 60 i had a good experience and head ache also reduced. again i have consulted with doctor he told me to continue for 2 years on demand without duralast since i had surgery in urethra, when i used only udzire ejaculation is happening quickly.

      Dear Doctor need your advise on the below,

      i haven't done any scanning or test after surgery, i have done only uroflow test, is it i need to continue this tablet for 2 years.
      one more thing i am working in duabi and i need to bring my wife to duabi can i carry udzire to duabi. is this tablet is approved in dubai.

      Delete
    3. Dear SK
      Duralast is a medicine which is designed to slightly reduce the speed of orgasm so without duralast You might experience slight premature ejaculation. you can try some physical methods to delay orgasm. having said this its my duty to tell that your doctor is the best judge to decide what tablet will suit you better. so please follow his advice. udzire or duralast does not stay in your system , so taking it for 2years is not an issue. You can take udzire to dubai. i dont think it comes under " DO NOT CARRY" list. so you can safely carry it. please get a prescription from your doctor for the drug. this will be useful in completing the airport formalities.

      Delete
    4. Thanks doctor, i have the prescription for the tablet. Sorry One more thing doctor how can conrol physically.

      Delete
    5. well.....
      means you try spending more time on foreplay and things to delay ejaculation like withdrawal and go again ..

      Delete
    6. Dear Doctor, which tablet can i take for premature ejaculation.

      Delete
    7. well that depends on your condition. Doctor who has examined you would be able to guide you better

      Delete
  17. Dear Doctor,

    I found one herbal pills in website called prolargentsize, is it work properly doctor

    ReplyDelete
    Replies
    1. i am really sorry.... i do not have experience in the field of Ayurveda.

      Delete
    2. which tablet i can take for premature ejaculation...

      Delete
    3. That cannot be generalised... Premature ejaculation is not like treating fever where we can universally administer paracetamol. Treatment of premature ejaculation is based on what is causing premature ejaculation.. Time to get a doctor consult!

      Delete
  18. The blog content seems quite informative to explore more about shorten refractory period . The post really helpful for me. Thanks for sharing the information

    ReplyDelete
    Replies
    1. welcome.. thats the idea of this blog on Diabetes (www.riyazsheena.blogspot.in)

      Delete
  19. Could i continue udzire & duralast together for long time without any side effect to prevent premature ejaculation?

    ReplyDelete
    Replies
    1. I think i received a mail from you and i have replied with details.

      Delete
    2. Dr.Riyaz.pls reply my question as early as possible & i would like to visit you.

      Delete
  20. doctor I want use this I no have any problem I can buy and use it for long time sex

    ReplyDelete
    Replies
    1. well that depends on the reason for the problem. the question whether you can use it for a long time or not needs review of your medical records and few tests to be on the safer side.

      Delete
  21. Replies
    1. it depends on the person using it. the pharma company claims udzire is better. I feel the drug action is more or less same. only the side effect profile may be better with udzire.. I felt patients responded better to tadalafil than sildenafil..

      Delete
  22. Doctor I am in my mid fifties and have erectile dysfunction and premature ejaculation problems.
    I dont have diabetes and have a mild bp for which was taking Aten 25 once a day, which is discontined now and am having normal bp levels.
    Can i take udzire or start with tazzle ? Raj

    ReplyDelete
    Replies
    1. Dear Raj,
      its safe to check for the reason for erectile dysfunction before you start treat these tablets. very very rarely even atenolol can lead to reduced sexual function. safe to consult your physician. most of us have reduced use of atenolol as it also said to increase risk of diabetes..

      Delete
  23. Dear Dr.Riyaz,

    Thanks for your response.

    Tablets like Udzire and manforce 50 (Slidanfil) helps to solve Erectyle Dysfunction alone or also help in Premature Ejaculation ?

    I tried Tazzle 10 mg with excellent effect without any side effects. I could get good errection and prologed activity. However lactation time was much longer.

    Understand Manforce and Udzire gives you continued errection and u can continue your activity longer and start again sooner.

    Kindly advise.

    Ofcourse, I will ensure proper doctor care before venturing into any of these tablets.

    Thanks a lot doctor... Raj

    ReplyDelete
    Replies
    1. Dear Mr.Raj,
      The effect of tablets vary slightly from person to person. tadalafil (Tazzle) gives better effect on prolonged use. Sildenafil doesn't have accumulatory effect. udenafil is still waiting for results of long term safety.

      Delete
  24. Doctor,

    I am 55 and quite healthy without diabetis or any other illness. But I do have ED and PE problems.
    Can I take Sildenafil 25 (Manforce 25) with Dapoxetine 30 (Sustinex) for a better performance.

    Thanks for your advice.

    Geevi

    ReplyDelete
    Replies
    1. my personal opinion would be to find out the cause of ED before trying tablets. The reason i am telling you this is because if the reason for your E.D is hormonal these tablets might not work. plus at 55 years you also need to do a stress test before taking these type of tablets.

      Delete
  25. Doctor, can I take Manforce 25 along with Sustinex 30 for a better performance ?

    Raj

    ReplyDelete
    Replies
    1. Dear Raj,
      i think we discussed this issue before. i strongly feel the reason for your erectile dysfunction has to been sorted out before trying these tablets.

      Delete
  26. Thanks Riyaz for helping our kind people, who feels alone in the world and can not share their ED problem with anyone :(. I am going to try Uzire and lets see :)

    ReplyDelete
    Replies
    1. you are always welcome!! do share your experience..

      Delete
  27. Dear Dr.Riyaz,

    I happened to go through this blog and am really happy and thanks for your advice for various issues.

    I stay away from my family on work and meet my wife once in 3-4 months only for a few days.I am 52 without any illness. But, oflate, I find ED and PE problems creeping in, may be because of age and work stress and am unable to enjoy. Is it safe to use Manforce and Sustinex tablets (suggested by my friend, who is using it with good effect). Since it will be only once or twice in 3-4 months, will it have any side effects? Thanks for your response doctor. Sunil

    ReplyDelete
    Replies
    1. Dear Sunil,
      I have mentioned this as reply to many queries on this very post. Please do not consider these tablets like paracetamol. These are category tablets which have to be started after proper evaluation.
      first thing is cause for your ED has to be evaluated. if the cause is hormonal or blockage of vessels this tablet might not work.
      secondly these tablets increase the load on your heart so although you do not have any illness you might be aggravating a small cardiac problem into something big.
      It is my sincere advise to all my readers that please do not think you are the only person with this type of problems. people feel shy to talk about sex and sexual problems. please consult a qualified urologist and endocrinologist before starting any of these pills.
      as far as your question on side effects is concerned Yes! all these tablets come with certain side effects which may vary from person to person. So please use professional help! personal consultation with a good doctor will definitely help you.
      All the best!

      Delete
  28. Dear Dr Riyaz, you are doing great service and cleared some queries just by reading your posts. Continue this good work. I too believe "Knowledge is Power" &the "Best things in Life are Free"and you are sharing it nicely and freely.
    Kudos to you.
    A Dr

    ReplyDelete
    Replies
    1. Dear Dr,
      Thank you for your encouragement.. my only concern when putting posts is that it should not be misunderstood. hopefully i have made my writeup clear..

      Delete
  29. Dear Dr. Riyaz,
    Thanks for your useful infformation. Can you tell me where can I get these tablet?

    ReplyDelete
    Replies
    1. Dear Sir,
      These tablets are available in all big pharmacies. Due to cost factor many pharmacies are not stocking it in bulk.

      Delete
  30. Hi sir ,
    I used UDIZIRE tablets 3 times but erection came after 5 to 6 hours why its coming like this useually my timmings before dinner 8 pm pls help me

    ReplyDelete
    Replies
    1. Hi,
      The effect of udenafil or sildenafil or tadalafil depends on the nitric oxide production. Have you assessed the reason for your E.D? The cause of E.D has to be treated first for these tablets to act better.

      Delete
  31. It is very Informative Post..... I Like this Post.... Thanks for Sharing this Informative Post with us.....

    ReplyDelete
  32. Dear Dr
    I am 48 yrs old and type 2 diabetic taking Duotrol and janumet50/500 tablet. Have sugar under control. For the past 2 yrs I am having ED problem. I want to try UDZIRE100mg. Can you please let me know where can I get this tablet in chennai. Please help me.

    ReplyDelete
    Replies
    1. Dear Sir,
      Udzire is available in all major pharmacies across Chennai. Having said that it is available I would also suggest you to visit your primary physician for a cardiac status assessment. It would be safer to take this class (udenafil, tadalafil and sildenafil) of drugs after proper cardiac assessment. Another point i wish to add is that the reason for E.D has to be found out as you said your sugars are under good control. Target blood sugars - Fasting <110mg/dl and Post prandial <160mg/dl. HbA1c <7%

      Delete
  33. Hi Doctor

    I am 34 yr old unmarried, i had sex with my lover, understood from my first time, i have PE then i started taking tablets, then i had sex with her for two years by using tablets. I have some personal commitment, so i postponed my marriage. I didn't have sex for next one year, but i started talking alcohols due to so many issues. I tried to have a sex with her, But i couldn't even using tablets. Now i wanted to get married, she is also urging me for marriage, we both were more than 30+ now. But now worry is how i can go for marriage if i am unable to have sex. I consulted two doctors, they told i have ED (4.0) and asked me to go for regular exercise and udzire tablts, if that is not working go for penile surgery. Please advice any other medicine to cure my prblm in next 3 months.
    Thank You

    ReplyDelete
    Replies
    1. If you both love each other then E.D is not a hurdle for your marriage.. secondly for your E.D you need to investigate with testosterone, LH,FSH, doppler to find out root cause. stop smoking and alcohol completely.

      Delete
    2. Sir, Thanks a lot for your reply. I did testosterone test, it is 5.140ng/ml-normal. Now i am taking shilajit gold tablet in morning and night. also trying himcolin gel with 30min exercise. Please advice what to do next.

      Delete
    3. Sexual function in male is a combination of psychological, hormonal, neuronal and vascular factors. Now since your testosterone is normal one of the hormones responsible has been ruled out... what about other hormones and other systems involved in sexual function. Time to keep in touch with endocrinologist and urologist. Secondly the damage done by the smoking and alcohol might take some time to wash off. In other words you need to give time for your body to recover. All the best!

      Delete
  34. Hi: Where can I get Udzire 100mg. Does it require prescription or is it available off the counter. I tried in some pharmacies and they do not have it.

    ReplyDelete
  35. Udzire is available in all big pharmacies. Your general physician can give you the prescription for Udzire

    ReplyDelete
  36. Hi,

    Where can i buy this drug in kolkata

    Am unable to buy at any drug store or line

    Thanks

    ReplyDelete
  37. I am a diabetic type 2 .on insulin 24 units for the last one year. Ed is there for the last 7 years. Can I take udezire

    ReplyDelete
  38. Dear Sir,
    you first need to control your sugars. secondly the reason for E.D must be found out before taking medicines like udezire. secondly some precautionary investigations need to be done before starting udezire. I would suggest you to meet an urologist or Endocrinologist to decide further course of treatment.

    ReplyDelete

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